Tecentriq

Generic name:atezolizumab [ A-te-zoe-LIZ-ue-mab ]
Drug class:Anti-PD-1 monoclonal antibodies

Medically reviewed by Judith Stewart, BPharm. Last updated on May 12, 2022.

What is Tecentriq?

Tecentriq is a monoclonal antibody that affects the actions of the body's immune system. It works to strengthen your immune system to help your body fight against tumor cells.

Tecentriq belongs to a class of drugs called programmed death-ligand 1 (PD-L1) inhibitors. It blocks interactions in the PD-1/PD-L1 pathway (proteins found on the body’s immune cells and some cancer cells) to help the body’s immune system fight cancer cells.

What is Tecentriq used to treat?

Tecentriq is used to treat adults with:

• a type of bladder and urinary tract cancer called urothelial carcinoma. Tecentriq may be used when your bladder cancer has spread or cannot be removed by surgery, and if you have any one of the following conditions:
  • you are not able to take chemotherapy that contains a medicine called cisplatin, and your cancer tests positive for “PD-L1”, or
  • you are not able to take chemotherapy that contains any platinum regardless of “PD-L1” status.
• a type of lung cancer called non-small cell lung cancer (NSCLC).
  • Tecentriq may be used alone as a treatment for your lung cancer:
    • to help prevent your lung cancer from coming back after your tumor(s) has been removed by surgery and you have received platinum-based chemotherapy, and
    • you have stage 2 to stage 3A NSCLC (talk to your healthcare provider about what these stages mean), and
    • your cancer tests positive for “PD-L1”.
  • Tecentriq may be used alone as your first treatment when your lung cancer:
    • has spread or grown, and
    • your cancer tests positive for “high PD-L1”, and
    • your tumor does not have an abnormal “EGFR” or “ALK” gene.
  • Tecentriq may be used with the medicines bevacizumab, paclitaxel, and carboplatin as your first treatment when your lung cancer:
    • has spread or grown, and
    • is a type called “non-squamous NSCLC”, and
    • your tumor does not have an abnormal “EGFR” or “ALK” gene.
  • Tecentriq may be used with the medicines paclitaxel protein-bound and carboplatin as your first treatment when your lung cancer:
    • has spread or grown, and
    • is a type called “non-squamous NSCLC”, and
    • your tumor does not have an abnormal “EGFR” or “ALK” gene.
  • Tecentriq may also be used alone when your lung cancer:
    • has spread or grown, and
    • you have tried chemotherapy that contains platinum, and it did not work or is no longer working.
    • if your tumor has an abnormal “EGFR” or “ALK” gene, you should have also tried an FDA-approved therapy ..