Generic name:inotersen [ IN-oh-TER-sen ]
Drug class:Miscellaneous metabolic agents
What is Tegsedi?
Tegsedi works by decreasing a protein called transthyretin (TTR, made primarily in the liver). Hereditary transthyretin-mediated amyloidosis (hATTR) is a rare condition in which abnormal deposits of TTR protein build up in many parts of the body, interfering with normal function.
Tegsedi injection is used to treat polyneuropathy (damage of multiple nerves throughout the body) in adults with hATTR. Tegsedi can help reduce symptoms such as pain, numbness, tingling, abnormal heartbeats, diarrhea, constipation, weakness, and problems with movement in your arms or legs.
Tegsedi is available only from a certified pharmacy under a special program.
Warnings
Tegsedi can make it easier for you to bleed, even from a minor injury. Seek medical attention if you have bleeding that will not stop. Bleeding may also happen inside your body, such as in your stomach or intestines, or in your brain.
Bleeding may also happen inside your body. Call your doctor at once if you have signs such as severe headache, neck stiffness, bleeding in the whites of your eyes, black or bloody stools, pink or brown urine, or coughing up blood or vomit that looks like coffee grounds.
Before taking this medicine
You should not use Tegsedi if you are allergic to inotersen, or if you have:
low levels of platelets in your blood (your doctor will test you for this); or
kidney problems caused by using Tegsedi in the past.
To make sure Tegsedi is saf...
