Avandaryl

Generic name:glimepiride and rosiglitazone [ glye-MEP-ir-ide-and-ROE-si-GLI-ta-zone ]
Drug class:Antidiabetic combinations

Medically reviewed by Drugs.com. Last updated on Jun 14, 2021.

What is Avandaryl?

Avandaryl contains a combination of glimepiride and rosiglitazone, two oral diabetes medicines that help control blood sugar levels.

Avandaryl is for people with type 2 diabetes. This medication is not for treating type 1 diabetes.

Avandaryl is not recommended for use with insulin. Taking Avandaryl while you are using insulin may increase your risk of serious heart problems.

Warnings

You should not use Avandaryl if you have severe or uncontrolled heart failure, or if you are allergic to sulfa drugs. Do not use this medicine if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Avandaryl can cause or worsen congestive heart failure. Stop using this medicine and call your doctor at once if you have shortness of breath (even with mild exertion), swelling, or rapid weight gain.

Before taking this medicine

You should not use Avandaryl if you are allergic to glimepiride or rosiglitazone, or:

• if you have advanced heart failure;

• if you are allergic to sulfa drugs; or

• if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

To make sure Avandaryl is safe for you, tell your doctor if you have:

• congestive heart failure, heart disease, a history of heart attack or stroke;

• an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);

• eye problems caused by diabetes;

• liver disease or kidney disease; or

• a adrenal or pituitary gland disorder.

Women may be more likely than men to have bone fractures in the upper arm, hand, or foot while taking Avandaryl. Talk with your doctor if you are concerned about this possibility.

Do not use Avandaryl if you are pregnant. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Tell your doctor if you are pregnant or plan to become pregnant.

Some women using Avandaryl have started having menstrual periods, even after not having a period for a long time due to a medical condition. You may be able to get pregnant if your periods restart. Talk with your doctor about the need for birth control.

It is not known whether glimepiride and rosiglitazone passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using Avandaryl.

How should I take Avandaryl?

Take Avandaryl exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take Avandaryl with your first meal of the day.

Your blood sugar will need to be chec...