Thiotepa
Generic name: thiotepa [ THYE-oh-TEP-a ]
Brand names: Tepadina, Thioplex
Dosage form: injectable powder for injection (100 mg; 15 mg; 30 mg)
Drug class:Alkylating agents
What is thiotepa?
Thiotepa is used to treat cancer of the breast, ovary, bladder, and certain body cavities.
Thiotepa may also be used for purposes not listed in this medication guide.
Warnings
Thiotepa can increase your risk of bleeding or infection. Call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, chills, mouth sores, pale skin, tiredness, feeling short of breath).
Before taking this medicine
You should not be treated with thiotepa if you are allergic to it, or if you have recently received a vaccine.
Tell your doctor if you have ever had:
a weak immune system; or
Tell your doctor about all other cancer treatments you have recently received, including chemotherapy and radiation.
Using thiotepa may increase your risk of developing other cancers, such as leukemia. Ask your doctor about this risk.
Tell your doctor if you are planning a pregnancy. Both men and women must prevent pregnancy during treatment with thiotepa and for several months afterward.
Thiotepa can harm an unborn baby if the mother or the father is using thiotepa.
If you are a woman, you may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 1 year after your last dose.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using thiotepa.
This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because thiotepa can harm an unborn baby.
You should not breastfeed while using thiotepa.
How is thiotepa given?
Thiotepa is given as an infusion into a vein, or injected directly into the bladder or other body cavity. A healthcare provider will give you this injection.
When injected into the bladder, you will need to hold the medicine inside your bladder for 2 hours. Tell your caregivers if this causes you a great deal of discomfort. You may need to receive a smaller amount of the medicine to hold it comfortably in your bladder...
