#
Thrombate III
  • Professionals
  • FDA PI

Thrombate III

Generic name:antithrombin iii (human)
Dosage form: injection
Drug class:Miscellaneous coagulation modifiers

Medically reviewed by Drugs.com. Last updated on May 1, 2022.

Indications and Usage for Thrombate III

Thrombate III is a human antithrombin (AT) indicated in patients with hereditary antithrombin deficiency for:

  • Treatment and prevention of thromboembolism
  • Prevention of peri-operative and peri-partum thromboembolism

Thrombate III Dosage and Administration

For intravenous use after reconstitution only

Dose

  • Each vial of Thrombate III has the functional activity, in International Units (units), stated on the label of the vial. The potency assignment has been determined with a standard calibrated against a World Health Organization antithrombin reference preparation. When prepared as directed, the approximate final concentration is 50 units per milliliter.
  • A guide for dosing Thrombate III is provided in Table 1.
Table 1: Dosing Guidelines
*
The dose calculation is based on an expected incremental in vivo recovery of 1.4% per unit per kilogram above baseline or trough levels.
Expressed as % normal level based on functional AT assay.
Regimen
(timing)
Target AT<..