Tolnaftate
Class: Thiocarbamates
ATC Class: D01AE18
VA Class: DE102
CAS Number: 2398-96-1
Brands: Tinactin, Ting
Introduction
Antifungal; thiocarbamate.
Uses for Tolnaftate
Dermatophytoses
Treatment of tinea corporis (body ringworm) and tinea cruris (jock itch) caused by Epidermophyton floccosum, Microsporum canis, M. audouinii, Trichophyton mentagrophytes, T. rubrum, or T. tonsurans.
Treatment of tinea pedis (athlete’s foot) and tinea manuum† (hand ringworm) caused by E. floccosum, M. canis, M. audouinii, T. mentagrophytes, T. rubrum, or T. tonsurans.
Available for self-medication (OTC use) for treatment of tinea corporis, tinea cruris, or tinea pedis and for prevention of reinfection of tinea pedis.
Should not be used for treatment of dermatophyte infections that occur on scalp or nails.
Topical antifungals usually effective for treatment of uncomplicated tinea corporis and tinea cruris. An oral antifungal may be necessary when tinea corporis or tinea cruris is extensive, dermatophyte folliculitis is present, infection is chronic or does not respond to topical therapy, or patient is immunocompromised because of coexisting disease or concomitant therapy.
Topical antifungals usually effective for treatment of uncomplicated tinea pedis. An oral antifungal may be necessary for treatment of hyperkeratotic areas on palms and soles, for chronic moccasin-type tinea pedis, and for treatment of tinea unguium (fingernail or toenail dermatophyte infections, onychomycosis).
Pityriasis (Tinea) Versicolor
Treatment of pityriasis (tinea) versicolor† caused by Malassezia furfur (Pityrosporum orbiculare or P. ovale).
Topical antifungals generally effective; an oral antifungal (with or without a topical antifungal) may be necessary in patients who have extensive or severe infections or have failed to respond to or have frequent relapses with topical therapy.
Tolnaftate Dosage and Administration
Administration
Topical Administration
Apply topically to the infected skin as a 1% cream, aerosol liquid spray, aerosol powder spray, powder, or solution.
Avoid contact with eyes, nose, mouth, and other mucous membranes. Do not apply to scalp or nail infections.
Clean affected areas with soap and water and dry thoroughly prior to applying preparation.
A small amount of the cream or powder or 2 or 3 drops of the solution should be rubbed gently into affected areas. Alternatively, a thin layer of aerosol liquid spray or aerosol spray powder should be applied.
Although pruritus, burning, and soreness may be relieved within 24–72 hours after initiation of therapy, complete the full course of treatment.
When treating tinea pedis, pay special attention to spaces between toes. Also, wear well-fitting, ventilated shoes and change shoes and socks at least once daily.
