Dosage form: injection, solution
Drug class:Loop diuretics
Medically reviewed by Drugs.com. Last updated on Dec 22, 2021.
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Torsemide Injection Description
Torsemide Injection is a diuretic of the pyridine-sulfonylurea class. Its chemical name is 1-isopropyl-3-
[(4-rn-toluidino-3-pyridyl) sulfonyl]urea and its structural formula is:
Its molecular formula is C,sH;!ON4 0 3S, its pKa is 6.42, and its molecular weight is 348.42.
Torsemide is a white to off-white c rys ta lline powder. Torsemide vials for intravenous injection contain a
sterile solution of torsemide (10 mglmL), polyethylene g lycal-400, tromethamine, and sodium hydroxide
(as needed to adjust p H ) in water for injection.
Torsemide Injection - Clinical Pharmacology
Mechanism of Action
Micropuncture studies in anima ls have shown that torsemide acts from within the lumen of the thick
ascending portion of the loop of Henle, where it inhibits the Na'JK'/2CI'-carrier system. Clinical
pharmacology studies have confirmed this site of action in humans, and effects in other segments of
the nephron have not been demonstrated. Diuretic activity thus correlates better with the rate of drug
excretion in the urine than with the concentration in the blood.
Torsemide increases the urinary excretion of sodium, chloride, and water, but it does not signifi
