Tridione

Generic name:trimethadione
Dosage form: tablet, chewable
Drug class:Oxazolidinedione anticonvulsants

Medically reviewed by Drugs.com. Last updated on Oct 22, 2021.

BECAUSE OF ITS POTENTIAL TO PRODUCE FETAL MALFORMATIONS AND SERIOUS SIDE EFFECTS, Tridione (trimethadione) SHOULD ONLY BE UTILIZED WHEN OTHER LESS TOXIC DRUGS HAVE BEEN FOUND INEFFECTIVE IN CONTROLLING PETIT MAL SEIZURES.

Tridione Description

Tridione (trimethadione) is an antiepileptic agent. An oxazolidinedione compound, it is chemically identified as 3,5,5-trimethyloxozolidine-2,4-dione, and has the following structural formula:

Tridione is a synthetic, water-soluble, white, crystalline powder. It is supplied in tablets for oral use only.

Inactive Ingredients

150 mg Dulcet Tablet: Corn starch, lactose, magnesium stearate, magnesium trisilicate, sucrose and natural/synthetic flavor.

Tridione - Clinical Pharmacology

Tridione has been shown to prevent pentylenetetrazol-induced and thujone-induced seizures in experimental animals; the drug has a less marked effect on seizures induced by picrotoxin, procaine, cocaine, or strychnine. Unlike the hydantoins and antiepileptic barbiturates, Tridione does not modify the maximal seizure pattern in patients undergoing electroconvulsive therapy.

Tridione has a sedative effect that may increase to the point of ataxia when excessive doses are used. A toxic dose of the drug in animals (approximately 2 g/kg) produced sleep, unconsciousness, and respiratory depression.

Trimethadione is rapidly absorbed from the gastrointestinal tract. It is demethylated by liver microsomes to the active metabolite, dimethadione.

Approximately 3% of a daily dose of Tridione is recovered in the urine as unchanged drug. The majority of trimethadione is excreted slowly by the kidney in the form of dimethadione.

INDICATIONS

Tridione (trimethadione) is indicated for the control of p...