Trikafta
Generic name:elexacaftor, ivacaftor, and tezacaftor [ e-LEX-a-KAF-tor, EYE-va-KAF-tor, and-TEXZ-a-KAF-for ]
Drug class:CFTR combinations
What is Trikafta?
Trikafta contains a combination of elexacaftor, ivacaftor, and tezacaftor.
Trikafta is a prescription medicine used to treat cystic fibrosis in adults and children at least 6 years old.
Trikafta is for use only in patients who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene or another mutation that is responsive to treatment with Trikafta.
Before you take this medicine, you may need a medical test to make sure you have this gene mutation.
Warnings
It is not known if Trikafta is safe and effective in children under 6 years of age.
Trikafta may affect the way other medicines work, and other medicines may affect how Trikafta works. Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Before taking this medicine
Some medicines can cause unwanted or dangerous effects when used with Trikafta. Your doctor may change your treatment plan if you also use:
rifabutin or rifampin;
St. John's wort; or
seizure medicine such as carbamazepine, phenobarbital, or phenytoin.
To make sure Trikafta is safe for you, tell your doctor if you have ever had::
liver disease; or
kidney disease.
Tell your doctor if you are pregnant or breastfeeding.
How should I take Trikafta?
Take Trikafta exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.
Trikafta is supplied as two separate daily tablets. The usual dose is 2 orange tablets in the morning and 1 blue tablet in the evening, 12 hours later. Follow your doctor's dosing instructions very carefully.
Swallow the Trikafta tablet whole and do not crush, chew, or break it.
Doses are based on weight and may change if your child gains or loses weight.
Your doctor may change your dose if you also take certain other medications. Your doctor may tell you to take the orange tablets and the blue tablet on separate days. Do not change your dose or dosing schedule without your doctor's advice.
Always take Trikafta with food that contains fat, such as butter, peanut butter, eggs, nuts, meat, whole milk,...
