Trimethobenzamide Capsules
Generic name: trimethobenzamide hydrochloride
Dosage form: capsule
Drug class:Anticholinergic antiemetics
Medically reviewed by Drugs.com. Last updated on Sep 21, 2021.
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Indications and Usage for Trimethobenzamide Capsules
Trimethobenzamide hydrochloride capsules is indicated in adults for the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.
Limitation of Use:
Trimethobenzamide hydrochloride capsules is not recommended for use in pediatric patients due to the risk of extrapyramidal signs and symptoms and other serious central nervous system (CNS) effects, and the risk of exacerbation of the underlying disease in pediatric patients with Reye's syndrome or other hepatic impairment.
Trimethobenzamide Capsules Dosage and Administration
Recommended Adult Dosage
The recommended adult dosage is 300 mg orally three or four times daily. Select the lowest effective daily dosage and adjust as needed based upon therapeutic response and tolerability.
Dosage Adjustment for Geriatric Patients and/or Patients with Renal Impairment
In geriatric patients and/or in patients with renal impairment (creatinine clearance 70 mL/min/1.73m2 or less), reduce the daily dosage of trimethobenzamide hydrochloride capsules by increasing the dosing interval and adjust as needed based upon therapeutic response and tolerability. Monitor renal function [see Use in Specific Populations (8.5, 8.6)].
Dosage Forms and Strengths
Capsules: 300 mg trimethobenzamide hydrochloride; the capsule has an opaque lavender cap and opaque lavender body with a white imprint "Novel 660" on cap and "300 mg on body.
Contraindications
Trimethobenzamide hydrochloride capsules are contraindicated in patients with known hypersensitivity to trimethobenzamide [see Adverse Reactions (6)].
