Turalio
Generic name:pexidartinib [ PEX-i-DAR-ti-nib ]
Drug class:Multikinase inhibitors
What is Turalio?
Turalio is a small molecule tyrosine kinase inhibitor that helps decrease tumor growth.
Turalio is used to treat giant cell tumor of the tendon sheath (also called tenosynovial giant cell tumor, or pigmented villonodular synovitis).
Turalio is available only under a special program. You must be registered in the program and understand the risks and benefits of this medicine.
Warnings
Turalio can cause severe or fatal effects on your liver. You will need frequent blood tests to check your liver function during treatment.
Stop using Turalio and call your doctor at once if you have dark urine or jaundice (yellowing of the skin or eyes).
Tell your doctor if you have other symptoms of liver problems, such as loss of appetite, stomach pain (upper right side), nausea, vomiting, tiredness, itching, or fever.
Before taking this medicine
To make sure Turalio is safe for you, tell your doctor if you have ever had:
liver disease; or
kidney disease.
Pexidartinib can harm an unborn baby if the mother or the father is using this medicine.
If you are a woman, you may need to have a negative pregnancy test before starting this treatment. Do not use Turalio if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 1 month after your last dose.
If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 1 week after your last dose.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Turalio.
Pexidartinib may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because pexidartinib can harm an unborn baby.
Do not breastfeed while using this medicine, and for at least 1 week after your last dose.
How should I take Turalio?
Take Turalio exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.
You must remain under the care of a doctor while taking this medicine.
Take Turalio on an empty stomach, at least 1 hour before or 2 hours after a meal.
Swallow the capsule whole and do not crush, chew, break, or open it.
If you vomit shortly after taking this medicine, do not take another dose. Wait until your next scheduled dose time to take the medicine again.
You will need blood tests to check your liver function before you start t...
