Tyzine
Generic name:tetrahydrozoline hydrochloride
Dosage form: nasal solution
Drug class:Nasal antihistamines and decongestants
Medically reviewed by Drugs.com. Last updated on Aug 23, 2021.
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Tyzine Description
Tyzine® Nasal Solution contains tetrahydrozoline hydrochloride, 2-(1,2,3,4-Tetrahydro-1, naphthyl)-2-imidazoline monohydrochloride, as a nasal decongestant. The chemical structure is:
Nasal Solution is available for topical nasal application as 0.1% nasal solution and as 0.05% pediatric nasal drops. The nasal solution is a solution of tetrahydrozoline hydrochloride in water, with sodium chloride, sodium citrate, edetate disodium, and benzalkonium chloride, with hydrochloric acid to adjust to the pH.
Tyzine - Clinical Pharmacology
Tyzine® Nasal Solution (tetrahydrozoline hydrochloride), a sympathomimetic amine, possesses vasoconstrictor and decongestant actions when applied to nasal mucosa, resulting in vasoconstriction of the smaller arterioles of the nasal passages. Information on the absorption, distribution and elimination of the drug is not available.
Indications and Usage for Tyzine
Tyzine® Nasal Solution is indicated for decongestion of nasal and nasopharyngeal mucosa.
Contraindications
Tyzine® Nasal Solution is contraindicated for patients who have shown previous hypersensitivity to its components. The 0.1% solution is contraindicated in children under six years of age. Tyzine® Nasal Solution is not to be used for infants under two years of age. Tyzine® Pediatric Nasal Drops (0.05%) should be used for children between the ages of 2 and 6 years (See "Dosage and Administration"). Tyzine® Nasal Solution should not be used by patients under treatment with Monoamine Oxidase (MAO) Inhibitors.
