Ubrogepant
Generic name: ubrogepant
Brand name: Ubrelvy
Dosage form: tablet
Drug class:CGRP inhibitors
What is ubrogepant?
Ubrogepant is a tablet used by adults to treat migraine headaches, it does not prevent migraines.
It was approved by the FDA in 2019 as studies showed that two hours after patients took ubrogepant, they had less pain and more freedom from their most bothersome migraine symptoms (eg. nausea, light sensitivity and sound sensitivity), when compared to other patients taking a placebo (dummy pill).
It is from the class of drugs called calcitonin gene-related peptide (CGRP) receptor antagonists. CGRP is a protein in the nerve endings that is involved in pain and migraines. Ubrogepant blocks the CGRP protein from attaching to the nerve endings and so decreases the pain and migraine symptoms
What is ubrogepant used for?
- ubrogepant is a prescription medicine used for the acute treatment of migraine attacks with or without aura in adults.
- it is not used to prevent migraine headaches.
- It is not known if this medicine is safe and effective in children.
Who should not take ubrogepant ?
Do not take ubrogepant if you are taking medicines known as a strong CYP3A4 inhibitor, such as:
- ketoconazole
- clarithromycin
- itraconazole
Ask your healthcare provider if you are not sure if you are taking any of these medicines. Your healthcare provider can tell you if it is safe to take ubrogepant with other medicines.
What should I tell my doctor before taking ubrogepant ?
Before you take ubrogepant tell your healthcare provider about all of your medical conditions, including if you:
- have liver problems
- have kidney problems
- are pregnant or plan to become pregnant. It is not known if ubrogepant will harm your unborn baby.
- are breastfeeding or plan to breastfeed. It is not known if ubrogepant passes into your breast milk.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. See the interactions section below about specific medications that interact with ubrogepant.
How should I take ubrogepant ?
Take ubrogepant exactly as your healthcare provider tells you to take it.
You can take your ubrogepant tablet with or without food.
Most patients can take a second tablet 2 hours after the first tablet, as needed.
You should not take a second tablet within 24 hours if you consume grapefruit or grapefruit juice or are taking medications that may include:
- Verapamil
- Cyclosporine
- Ciprofloxacin
- Fluconazole
- fluvoxamine
It is not known if it is safe to take ubrogepant for more than 8 migraine headaches in 30 days.
You should write down when you have headaches and when you take ubrogepant so you can talk to your healthcare provider about how ubrogepant is working for you.
If you take too much ubrogepant, call your he...
