Ultra-TechneKow DTE
Generic name: technetium Tc-99m
Dosage form: injection, solution
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Ultra-TechneKow DTE Description
The Ultra-Technekow™ DTE Generator is prepared with fission-produced molybdenum Mo-99 adsorbed onto alumina column shielded by lead, tungsten, or depleted uranium. This generator provides a closed system for the production of sterile metastable technetium Tc-99m, which is produced by the decay of molybdenum Mo-99. Sterile, non-pyrogenic isotonic solutions of Sodium Pertechnetate Tc 99m can be obtained conveniently by periodic aseptic elution of the generator. These solutions should be clear, colorless, and free from any particulate matter.
The carrier-free solution may be used as is, or diluted to the proper concentration. Over the life of the generator, an elution will contain an amount of technetium Tc-99m in direct proportion to the quantity of Mo-99 decay since the previous elution of the generator. The quantity of Tc-99m in the eluate is determined by quantity of Mo-99 on the column and the elapsed time between elutions.
Each eluate of the generator should not contain more than the USP limit of
0.15 kilobecquerel molybdenum Mo-99 per megabecquerel technetium Tc-99m
(0.15 microcurie Mo-99 per millicurie Tc-99m) per administered dose at the time of administration and an aluminum ion concentration of not more than 10 micrograms per milliliter of the generator eluate, both of which must be determined by the user before administration.
Since the eluate does not contain an antimicrobial agent, it should not be used after
12 hours from the time of generator elution.
Physical Characteristics
Technetium Tc-99m decays by isomeric transition with a physical half-life of 6 hours. The principal photon that is useful for detection and imaging studies is listed in Table 1.
Table 1. Principal Radiation
Emission Data
Radiation | Mean Percent | Energy (keV) |
Gamma-2 | 89.07 |
MEDICAL DEPARTMENTS
Cardiology
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Pre-natal Care
Ultrasound Echocardiogram
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