Uniprim Powder
Generic name: trimethoprim and sulfadiazine powder
Dosage form: FOR ANIMAL USE ONLY
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Uniprim Powder Description
Uniprim Powder contains 67 mg trimethoprim and 333 mg sulfadiazine per gram.
Uniprim Powder is a combination of trimethoprim and sulfadiazine in the ratio of 1 part to 5 parts by weight, which provides effective antibacterial activity against a wide range of bacterial infections in animals.
Trimethoprim is 2,4 diamino-5-(3, 4, 5-trimethoxybenzyl) pyrimidine.
ACTIONS
Microbiology: Trimethoprim blocks bacterial production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the enzyme dihydrofolate reductase.
Sulfadiazine, in common with other sulfonamides, inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid.
Trimethoprim/sulfadiazine thus imposes a sequential double blockade on bacterial metabolism. This deprives bacteria of nucleic acids and proteins essential for survival and multiplication, and produces a high level of antibacterial activity which is usually bactericidal.
Although both sulfadiazine and trimethoprim are antifolate, neither affects the folate metabolism of animals. The reasons are: animals do not synthesize folic acid and cannot, therefore, be directly affected by sulfadiazine; and although animals must reduce their dietary folic acid to tetrahydrofolic acid, trimethoprim does not affect this reduction because its affinity for dihydrofolate reductase of mammals is significantly less than for the corresponding bacterial enzyme.
Trimethoprim/sulfadiazine is active against a wide spectrum of bacterial pathogens, both gram-negative and gram-positive. The following in vitro data are available, but their clinical significance is unknown. In general, species of the following genera are sensitive to trimethoprim/sulfadiazine:
| Very Sensitive | Sensitive | Moderately Sensitive | Not Sensitive |
| Escherichia | Staphylococcus | Moraxella | Mycobacterium |
| Streptococcus | Neisseria | Nocardia | Leptospira |
| Proteus |
MEDICAL DEPARTMENTS
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