Vaprisol

Generic name:conivaptan [ koe-NYE-vap-tan ]
Drug class:Vasopressin antagonists

Medically reviewed by Drugs.com. Last updated on Feb 21, 2022.

What is Vaprisol?

Vaprisol is a vasopressin antagonist that reduces the level of a hormone that regulates the balance of water and salt (sodium) in the body. High levels of this hormone can cause an imbalance that results in low sodium levels and fluid retention.

Vaprisol is used to treat hyponatremia (low sodium levels).

Vaprisol improves urine flow without causing the body to lose too much sodium as you urinate.

Warnings

You should not receive Vaprisol if you are allergic to corn products, or if you are unable to urinate.

Serious drug interactions can occur when certain medicines are used together. Tell your doctor about all your current medicines and any you start or stop using.

Before you receive Vaprisol, tell your doctor if you have congestive heart failure, liver disease, kidney disease, alcoholism, or if you are malnourished.

To be sure Vaprisol is helping your condition, your blood will need to be tested often. Tell your caregivers at once if you have a serious side effect such as confusion, extreme thirst, muscle weakness or limp feeling, trouble speaking or swallowing, mood changes, or swelling or discomfort where the IV needle is placed. There are many other drugs that should not be used together with conivaptan, including certain antibiotics or antifungal medicines, heart or blood pressure medication, and HIV/AIDS medicine.

Before taking this medicine

You should not receive Vaprisol if you are allergic to corn products, or if you are unable to urinate.

Some medicines can cause unwanted or dangerous effects when used with Vaprisol. Your doctor may need to change your treatment plan if you use any of the following drugs:

• lomitapide;

• medicine to treat depression or mental illness - nefazodone, lurasidone, pimozide;

• an antibiotic - clarithromycin, erythromycin, telithromycin;

• antifungal medicine - itraconazole, ketoconazole, voriconazole;

• heart or blood pressure medicine - dronedarone, eplerenone, nimodipine, ranolazine;

• HIV/AIDS medicine - atazanavir, cobicistat, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, ritonavir;

• medicine to treat hepatitis C - boceprevir, telaprevir; or

• prostate medicine - alfuzosin, silodosin.

To make sure Vaprisol is safe for you, tell your doctor if you have:

• congestive heart failure;

• liver disease;

• kidney disease;

• alcoholism;

• HIV or AIDS;

• malnourishment; or

• a condition for which you take digoxin (digitalis).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Vaprisol may affect fertility (ability...