Varubi
Generic name:rolapitant (oral - tablets) [ roe-LA-pi-tant ]
Drug class:NK1 receptor antagonists
What is Varubi?
Varubi blocks the actions of chemicals in the body that trigger nausea and vomiting.
Varubi is used together with other medicines to prevent nausea and vomiting caused by cancer chemotherapy.
It is not known if Varubi is safe and effective in children.
Warnings
Varubi can cause a rapid and severe allergic reaction. Tell your doctor if you have a history of allergies to any food or medicines.
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Before taking this medicine
Some medicines can cause unwanted or dangerous effects when used with Varubi. Your doctor may change your treatment plan if you also use:
pimozide; or
Varubi is not approved for use by anyone younger than 2 years old.
To make sure this medicine is safe for you, tell your doctor if you have ever had:
liver disease; or
if you use a blood thinner (such as warfarin) and you have routine "INR" or prothrombin time tests.
Tell your doctor if you are pregnant or breastfeeding.
This medicine may affect fertility (your ability to have children) for a short time.
How should I take Varubi?
Take Varubi tablets exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.
Varubi is usually given on Day 1 of your chemotherapy treatment.
You may take the tablets with or without food.
You should not take Varubi more than once every 14 days.
You will be given other medication to prevent nausea or vomiting. Keep using these medicines for as long as your doctor has prescribed.
Store at room temperature away from moisture and heat. Keep each tablet in the foil blister pack until you are ready to take the medicine.
Dosing information
Usual Adult Dose for Nausea/Vomiting -- Chemotherapy Induced:
Oral: 180 mg orally within 2 hours prior to initiation of chemotherapy on Day 1
Parenteral: 166.5 mg via IV infusion (over 30 minutes) within 2 hours prior to initiation of chemotherapy on Day 1
ADDITIONAL MEDICATIONS:
Highly Emetogenic Cancer Chemotherapy (HEC):
-Day 1: Dexamethasone 20 mg orally 30 minutes prior to
