Vilanterol
Class: Selective beta-2-Adrenergic Agonists
VA Class: RE102
Chemical Name: α,α-Diphenylbenzeneacetic acid compd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol (1:1)
Molecular Formula: C24H33Cl2NO5•C20H16O2
CAS Number: 503070-58-4
Brands: Breo Ellipta (combination)
Introduction
Bronchodilator; a relatively selective, long-acting β2-adrenergic agonist.
Uses for Vilanterol
Bronchospasm in COPD
Vilanterol/fluticasone or vilanterol/umeclidinium fixed-combination therapy: Long-term maintenance treatment of airflow obstruction associated with COPD, including chronic bronchitis and emphysema.
Vilanterol/fluticasone fixed-combination therapy: Reduction of COPD exacerbations in patients with a history of exacerbations.
Vilanterol/fluticasone or vilanterol/umeclidinium fixed-combination therapy: Not indicated for treatment of acute bronchospasm (i.e., as rescue therapy for treatment of acute episodes of bronchospasm).
Other Uses
Vilanterol/umeclidinium fixed-combination therapy: Not indicated for treatment of asthma†; safety and efficacy in asthma not established.
Vilanterol Dosage and Administration
Administration
Administer vilanterol in fixed combination with fluticasone by oral inhalation only using a specific preloaded inhaler (Breo Ellipta) that delivers powdered vilanterol/fluticasone in fixed combination from foil-wrapped blisters.
Administer vilanterol in fixed combination with umeclidinium by oral inhalation only using a specific preloaded inhaler (Anoro Ellipta) that delivers powdered vilanterol/umeclidinium in fixed combination from foil-wrapped blisters.
Administer vilanterol in fixed combination with fluticasone or umeclidinium once daily at the same time every day.
Oral Inhalation
Oral Inhalation Administration
Before first use of either the Breo Ellipta or Anoro Ellipta inhaler, remove device from foil tray; discard enclosed desiccant out of reach of children and pets. Write date the tray is opened and inhaler is to be discarded (6 weeks after opening) on label. Do not open inhaler cover until immediately before use; to avoid wasting doses, do not close cover again until dose is inhaled.
Open cover fully to expose the mouthpiece and expect to hear a click. If dose counter does not advance when click is heard, inform clinician that dose is not properly prepared.
Before inhaling dose, exhale completely; do not exhale into mouthpiece of inhaler. Place mouthpiece between lips and inhale deeply through inhaler with a steady, even breath; do not inhale through nose. Do not block air vent on inhaler during inhalation. Remove inhaler from mouth, hold the breath for about 3–4 seconds (or as long as comfortable), then exhale slowly and gently.
Do not administer another dose even if delivery of dose not perceived. After dose is administered, close inhaler by sliding cover over mouthpiece as far as possible.
After inhalation of vilanterol/fluticasone in fixed combination, rinse mouth with water without swallowing.
Routine cleaning of inha...
