Virti-Sulf Cream
Generic name:sulfacetamide sodium and sulfur
Dosage form: cream
Drug class:Topical antibiotics
Medically reviewed by Drugs.com. Last updated on Aug 23, 2021.
Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.
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The Virti-Sulf brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Virti-Sulf Cream Description
Sodium sulfacetamide is a sulfonamide with antibacterial activity while sulfur acts as a keratolytic agent. Chemically, sodium sulfacetamide is N-[(4-aminophenyl) sulfonyl]- acetamide, monosodium salt, monohydrate.
The Structural formula is:
Each gram of VIRTI-SULF (sodium sulfacetamide 10% and sulfur 5%) Emollient Cream contains 100mg of Sodium Sulfacetamide and 50 mg of Sulfur in a base containing BHT, Cetyl Alcohol, Disodium EDTA, Fragrance, Glycerin, Glyceryl Stearate, Isostearyl Palmitate, PEG-100 Stearate, Methylparaben, Propylene Glycol, Propylparaben, Sodium Thiosulfate, Water, Xanthan Gum.
Virti-Sulf Cream - Clinical Pharmacology
Sodium sulfacetamide exhibits antibacterial activity. It is believed to block bacterial growth by acting as a competitive antagonist of para-aminobenzoic acid (PABA). While absorption through intact skin has not been determined for sodium sulfacetamide, it is estimated that 1% of topically applied sulfur is absorbed. Although the exact mode of the keratolytic activity of sulfur is unknown, it is reported to result from the interaction of sulfur with the cysteine content of keratinocytes. In combination with sulfacetamide, sulfur has been reported to inhibit P. acnes, thereby reducing the associated inflammation.
INDICATIONS
VIRTI-SULF (sodium sulfacetamide 10% and sulfur 5%) Emollient Cream is indicated in the topical control of acne vulgaris, acne rosacea and seborrheic dermatitis.
