Vonjo

Generic name:pacritinib
Dosage form: capsules
Drug class:Multikinase inhibitors

Medically reviewed by Judith Stewart, BPharm. Last updated on Mar 7, 2022.

What is Vonjo?

Vonjo is a prescription medicine used to treat adults with certain types of myelofibrosis who have a platelet count below 50 x 10⁹/L.

It is not known if this medicine is safe and effective in children.

Before taking Vonjo

Before you start treatment, tell your healthcare provider about all of your medical conditions, including if you:

smoke or were a smoker in the past
have had any other cancers. See Possible increased risk of new (secondary) cancers in the section Vonjo side effects.
have had a blood clot, heart attack, other heart problems, or stroke
have an infection. See Risk of infection in the section Vonjo side effects.
have diarrhea or commonly have loose stools
have nausea or vomiting
have active bleeding, have had severe bleeding, or plan to have surgery. You should stop taking Vonjo 7 days before any planned surgery or invasive procedures (such as a heart catheterization, stent placement in a coronary artery in your heart, or a procedure for varicose veins). See Vonjo side effects.
have liver or kidney problems
are pregnant or plan to become pregnant. It is not known if Vonjo will harm your unborn baby
are breastfeeding or plan to breastfeed. It is not known if Vonjo passes into your breast milk. You should not breastfeed during treatment and for 2 weeks after your last dose. Talk to your healthcare provider about the best way to feed your baby during this time.

What other drugs will affect Vonjo?

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking Vonjo with certain other medicines may affect the amount of Vonjo in your blood, and may increase your risk of side effects or affect how well Vonjo works.

Know the medicines you take. Keep a list of the medicines you take to show your healthcare provider and pharmacist when you get a new medicine.

Especially tell your doctor of if you are taking any of the following medicines:

macrolide antibiotics (clarithromycin, erythromycin)
antifungal medicines (itraconazole, ketoconazole, posaconazole, voriconazole)
HIV medicines that contain atazanavir, darunavir, efavirenz, etravirine, indinavir, nelfinavir, nevirapine, ritonavir, saquinavir, or cobicistat
heart or blood pressure medicines (quinidine, amiodarone, diltiazem, verapamil)
cimetidine
mifepristone
nefazodone
cannabidiol
cyclosporine
phenytoin
rifampin