Vontrol

Generic name:diphenidol
Dosage form: Tablets

Medically reviewed by Drugs.com. Last updated on May 23, 2022.

‘Vontrol’ may cause hallucinations, disorientation, or confusion. For this reason, its use is limited to patients who are hospitalized or under comparable, continuous, close, professional supervision. Even then, the physician should carefully weigh the benefits against the possible risks and give due consideration to alternate therapeutic measures.

Vontrol Description

Diphenidol, α, α-diphenyl-1-piperidinebutanol, is a compound not related to the antihistamines, phenothiazines, barbiturates, or other agents with antivertigo or antiemetic action. It has this configuration:

Each round, orange ‘Vontrol’ tablet is debossed SKF and 25 and contains diphenidol hydrochloride equivalent to diphenidol, 25 mg. Inactive ingredients consist of acacia, calcium sulfate, cellulose, FD&C Yellow No. 5 (tartrazine), FD&C Yellow No. 6, magnesium stearate and starch.

ACTIONS

‘Vontrol’ (diphenidol, SK&F) apparently exerts a specific antivertigo effect on the vestibular apparatus to control vertigo and inhibits the chemoreceptor trigger zone to control nausea and vomiting.

INDICATIONS (SEE WARNINGS)

1. VERTIGO—‘Vontrol’ is indicated in peripheral (labyrinthine) vertigo and associated nausea and vomiting, as seen in such conditions as: Meniere’s disease, middle- and inner-ear surgery (labyrinthitis).
2. NAUSEA AND VOMITING—‘Vontrol’ is indicated in the control of nausea and vomiting, as seen in such conditions as: postoperative states, malignant neoplasms and labyrinthine disturbances.

Contraindications

Known hypersensitivity to the drug is a contraindication. Anuria is a contraindication. (Since approximately 90% of the drug is excreted in the urine, renal shutdown could cause systemic accumulation.)

Warnings

‘Vontrol’ (diphenidol, SK&F) may cause hallucinations, disorientation or confusion. For this reason, its use is limited to patients who are hospitalized or under comparable, continuous, close, professional supervision. Even then, the physician should carefully weigh the benefits against the possible risks and give due consideration to alternate therapeutic measures.

Th...