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Wellbutrin
  • Treatments
  • Depression

Wellbutrin

Generic name:bupropionbyoo-PRO-pee-on ]
Brand names: Wellbutrin SR, Wellbutrin XL
Drug class:Miscellaneous antidepressants

Medically reviewed by Melisa Puckey, BPharm. Last updated on May 24, 2022.

What is Wellbutrin?

Wellbutrin is an antidepressant medicine that is thought to work in the brain and nerves on the chemical messengers norepinephrine and dopamine. Wellbutrin XL  is used to treat major depressive disorder (MDD) and seasonal affective disorder, and Wellbutrin SR is only used to treat major depressive disorder (MDD).

Another brand of bupropion called Zyban is used to help to stop smoking, Wellbutrin is not indicated to help quit smoking.

Warnings

You should not take Wellbutrin if you have seizures, an eating disorder, or if you have suddenly stopped using alcohol, seizure medications, or sedatives. If you take Wellbutrin for depression, do not also take Zyban to quit smoking.

Do not use Wellbutrin if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Wellbutrin may cause seizures, especially in people with certain medical conditions or when using certain drugs. Tell your doctor about all of your medical conditions and the drugs you use.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using this medicine. Your family or other caregivers should also be alert to ch...