Generic name:safinamide [ sa-FIN-a-mide ]
Drug class:Dopaminergic antiparkinsonism agents
Medically reviewed by Drugs.com. Last updated on Aug 30, 2021.
What is Xadago?
Xadago is monoamine oxidase inhibitor type B (MAO-B). This medicine works by allowing a chemical called dopamine (DOE pa meen) to work for longer periods of time in the brain. Low levels of dopamine in the brain are associated with Parkinson's disease.
Xadago is given with levodopa and carbidopa to treat "wearing-off" episodes (muscle stiffness, loss of muscle control) in people with Parkinson's disease.
Warnings
You should not use Xadago if you have severe liver disease.
TELL YOUR DOCTOR ABOUT ALL OTHER MEDICINES YOU USE. Some medicines can cause unwanted or dangerous effects (including death) when used within 14 days of when you take Xadago.
Before taking this medicine
You should not use Xadago if you are allergic to safinamide, or if you have:
severe liver disease.
Some medicines can cause unwanted or dangerous effects (including death) when used with Xadago. You should not use any of the following medicines within 14 days before or 14 days after you take Xadago:
amphetamines (Adderall, Dexedrine, and others);
cough medicine that contains dextromethorphan;
cyclobenzaprine;
methylphenidate (Concerta, Ritalin, Daytrana, and others);
St. John's wort;
another MAO inhibitor - isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others;
certain antidepressants such as amitriptyline (Elavil), desipramine (Norpramin), desvenlafaxine (Pristiq), duloxetine (Cymbalta), levomilnacipran (Fetzima), maprotiline (Ludiomil) , milnacipran (Savella), trimipramine (...
