Generic name:crizotinib [ kriz-OH-ti-nib ]
Drug class:Multikinase inhibitors
What is Xalkori?
Xalkori is a cancer medication that interferes with the growth and spread of cancer cells in the body.
Xalkori is used to treat non-small cell lung cancer that has spread to other parts of the body and is caused by a defect in either a gene called ALK (anaplastic lymphoma kinase) or a gene called ROS1.
Xalkori is also used to treat anaplastic large cell lymphoma (ALCL) in children 1 year of age and older and young adults when your ALCL with a defect in a gene called ALK has returned, or you have tried a treatment and it did not work or is no longer working.
Xalkori may also be used for purposes not listed in this medication guide.
It is not known if Xalkori is safe and effective in children under 12 months of age or in older adults with ALCL.
Warnings
Xalkori can cause serious heart or liver problems. Call your doctor at once if you have: fast or pounding heartbeats, sudden dizziness, shortness of breath, tiredness, itching, upper stomach pain, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).
Do not use Xalkori if you are pregnant. It could harm the unborn baby. Use effective birth control while you are using this medicine and for at least 3 months after your treatment ends, whether you are a man or a woman.
Before you take Xalkori, tell your doctor if you have liver or kidney disease, a heart rhythm disorder, an electrolyte imbalance (such as low levels of potassium or magnesium in your blood), or a personal or family history of Long QT syndrome.
