Yosprala

Generic name:aspirin and omeprazole [ AS-pir-in-and-oh-MEP-ra-zole ]
Drug class:Platelet aggregation inhibitors

Medically reviewed by Philip Thornton, DipPharm. Last updated on Feb 4, 2021.

What is Yosprala?

Yosprala contains a combination of aspirin and omeprazole. Aspirin is as platelet aggregation inhibitor. It also reduces substances in the body that cause pain, fever, and inflammation. Omeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

Yosprala is used to help lower the risk of heart problems, strokes, or death in people who have had certain conditions related to blood clots, including angina (chest pain), a past heart attack, or a stroke or a "mini stroke."

Yosprala is also used in people who have had surgery to improve blood flow to the heart and also have another condition that is already being treated with aspirin.

Omeprazole helps reduce the risk of stomach ulcers that may be caused by aspirin, especially in people who are 55 or older, or those who have had stomach ulcers in the past.

Warnings

You should not use Yosprala if you take medicine that contains rilpivirine, or if you've ever had an asthma attack or severe allergic reaction after taking aspirin or another NSAID (nonsteroidal anti-inflammatory drug).

Aspirin can make you bleed more easily. Call your doctor if you have any unusual bleeding or bruising, or if you cough up blood or have bloody or tarry stools.

Omeprazole can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine.

Diarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it.

Omeprazole may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight.

You may be more likely to have a broken bone while taking Yosprala long term or more than once per day.

Do not stop using Yosprala suddenly, even if you feel fine.

Before taking this medicine

You should not use Yosprala if you are allergic to aspirin or omeprazole, or if:

• you are also allergic to medicines like esomeprazole, lansoprazole, pantoprazole, rabeprazole, Nexium, Prevacid, Protonix, and others;

• you take medicine that contains rilpivirine (Edurant, Complera, Juluca...