Zepatier

Generic name:elbasvir and grazoprevir [ ELB-as-vir-and-graz-OH-pre-vir ]
Drug class:Antiviral combinations

Medically reviewed by Judith Stewart, BPharm. Last updated on Feb 23, 2022.

What is Zepatier?

Zepatier contains a combination of elbasvir and grazoprevir. Elbasvir and grazoprevir are antiviral medicines that prevent hepatitis C (HCV) from multiplying in your body.

Zepatier is used to treat chronic hepatitis C (HCV) in adults and children 12 years of age and older or weighing at least 66 pounds (30 kilograms). This medicine is sometimes given together with another drug called ribavirin.

Zepatier treats specific genotypes (1 or 4) of HCV infection, and only in certain people. Use only the medications prescribed for you. Do not share your medicine with other people.

Zepatier is sometimes used in people who also have HIV. This medicine is not a treatment for HIV or AIDS.

Warnings

You should not use Zepatier if you have moderate or severe liver disease.

Serious drug interactions can occur when certain medicines are used together with elbasvir and grazoprevir. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.

If you've ever had hepatitis B, using Zepatier can cause this virus to become active or get worse. Tell your doctor if you don't feel well and you have right-sided upper stomach pain, vomiting, loss of appetite, or yellowing of your skin or eyes.

Before taking this medicine

You should not use Zepatier if you are allergic to elbasvir or grazoprevir, or if you have:

• moderate or severe liver disease.

When Zepatier with ribavirin: To make sure all medicines are safe for you, tell your doctor about all your medical conditions, and if you are pregnant or breastfeeding.

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with elbasvir and grazoprevir.

Your doctor may change your treatment plan if you also use:

• cyclosporine;

• rifampin;

• St. John's wort;

• HIV or AIDS medication - atazanavir, darunavir, efavirenz, lopinavir, saquinavir, tipranavir; or

• seizure medicine - carbamazepine, phenytoin.

Tell your doctor if you have ever had:

• hepatitis B;

• liver problems other than hepatitis C;

• HIV (hum...