Zestoretic

Generic name:hydrochlorothiazide and lisinopril [ HYE-droe-KLOR-oh-THYE-a-zide-and-lye-SIN-oh-pril ]
Drug class:ACE inhibitors with thiazides

Medically reviewed by Philip Thornton, DipPharm. Last updated on Mar 1, 2021.

What is Zestoretic?

Zestoretic contains a combination of hydrochlorothiazide and lisinopril. Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Lisinopril is in an ACE inhibitor. ACE stands for angiotensin converting enzyme. Lisinopril lowers blood pressure and also relieves symptoms of fluid retention.

Zestoretic is used to treat hypertension (high blood pressure). Lowering blood pressure may lower your risk of a stroke or heart attack.

Zestoretic may also be used for purposes not listed in this medication guide.

Warnings

Do not use Zestoretic if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.

You should not use Zestoretic if you have ever had angioedema, if you are unable to urinate, or if you are allergic to sulfa drugs or to any ACE inhibitor. Do not take hydrochlorothiazide and lisinopril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).

If you have diabetes, do not use Zestoretic together with any medication that contains aliskiren (a blood pressure medicine).

Before taking this medicine

You should not ...