Zgesic

Generic name:acetaminophen and phenyltoloxamine citrate
Dosage form: tablet
Drug class:Analgesic combinations

Medically reviewed by Drugs.com. Last updated on Jun 21, 2021.

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.

Zgesic Description

Each tablet contains:

Acetaminophen ..... 600 mg

Phenyltoloxamine Citrate ..... 66 mg

In a specially prepared base to provide a prolonged therapeutic effect.

Inactive ingredients in each tablet are: calcium phosphate dibasic, magnesium stearate, methylcellulose, povidone and silicified microcrystalline cellulose.

Acetaminophen, 4’-hydroxyacetanilide, a slightly bitter, white, odorless, crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic. It has the following structural formula:

Figure 1: Acetaminophen

C8H9NO2 MW=151.17

Phenyltoloxamine Citrate, N, N-dimethyl-2-(α-phenyl-o-tolyloxy) ethylamine dihydrogen citrate, is an antihistamine used to augment analgesia. It occurs as crystals from water or methanol. It is soluble in water. Phenyltoloxamine Citrate has the following structural formula:

Figure 2: Phenyltoloxamine Citrate

C17H21NO•C6H8O7 MW=447.48

Zgesic - Clinical Pharmacology

The analgesic action of acetaminophen involves peripheral influences, but the specific mechanism is as yet undetermined. Antipyretic activity is mediated through hypothalamic heat regulating centers. Acetaminophen inhibits prostaglandin synthetase. Ther...