Betamethasone Valerate Lotion

Generic name: betamethasone valerate
Dosage form: lotion
Drug class:Topical steroids

Medically reviewed by Drugs.com. Last updated on Jan 1, 2022.

Rx Only

FOR DERMATOLOGIC USE ONLY NOT FOR OPHTHALMIC USE

DESCRIPTION:

Betamethasone Valerate Lotion contains betamethasone valerate USP, a synthetic adrenocortico-steroid for dermatologic use. Betamethasone, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity.

Betamethasone valerate is a white to practically white odorless crystalline powder practically insoluble in water, freely soluble in acetone and chloroform, soluble in alcohol, and slightly soluble in benzene and ether. Chemically, it is 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-valerate. The structural formula is:

Each gram of the 0.1% Lotion contains 1.2 mg of betamethasone valerate (equivalent to 1 mg betamethasone) in a vehicle of isopropyl alcohol and water slightly thickened with carbomer 934P. Phosphoric acid or sodium hydroxide is used to adjust the pH.

CLINICAL PHARMACOLOGY:

Topical corticosteroids share anti-inflammatory, anti-pruritic, and vasoconstrictive actions.

The mechanism of anti-infla...