Bimectin
Generic name: ivermectin topical solution
Dosage form: FOR ANIMAL USE ONLY
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Bimectin®
(ivermectin topical solution)
POUR-ON FOR CATTLE
Approved by FDA under ANADA # 200-318
Contains 5 mg ivermectin/mL
Parasiticide
Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.
INTRODUCTION
Bimectin® (ivermectin topical solution) Pour-On delivers internal and external parasite control in one convenient low-volume application. Bimectin® (ivermectin topical solution) Pour-On contains ivermectin, a unique chemical entity.
MODE OF ACTION
Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA). The margin of safety for compounds of this class is attributable to the fact that mammals do not have the glutamate-gated chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.
INDICATIONS
Bimectin® (ivermectin topical solution) Pour-On applied at the recommended dose level of 500 mcg/kg is indicated for the effective treatment and control of these parasites.
Gastrointestinal Roundworms | |
Ostertagia ostertagi (including inhibited stage) | (adults and L4) |
Haemonchus placei | (adults and L4) |
Trichostrongylus axei | (adults and L4) |
T. colubriformis | (adults and L
|
