Brexanolone
Generic name: brexanolone [ brex-AN-oh-lone ]
Brand name: Zulresso
Dosage form: intravenous solution (5 mg/mL)
Drug class:Miscellaneous antidepressants
What is brexanolone?
Brexanolone is used to treat postpartum depression.
Brexanolone is available only under a special program because it can cause excessive drowsiness or sudden loss of consciousness. You must be registered in the program and understand the risks and benefits of brexanolone.
Brexanolone may also be used for purposes not listed in this medication guide.
Warnings
Brexanolone is given in a hospital or clinic setting where you can be watched closely for side effects.
Brexanolone can make you very drowsy, and may cause you to pass out. Tell your caregivers if you feel light-headed or feel like you cannot stay awake.
Before taking this medicine
Brexanolone is not approved for use by anyone younger than 18 years old.
Tell your doctor if you have ever had:
kidney disease; or
if you drink large amounts of alcohol.
Some young people have thoughts about suicide while using an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.
Brexanolone may harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of brexanolone on the baby.
It may not be safe to breastfeed while using brexanolone. Ask your doctor about any risk.
How is brexanolone given?
Brexanolone is given as an infusion into a vein. A healthcare provider will give you this injection in a hospital or clinic setting.
Brexanolone is usually given around the clock for a total of 60 hours (2.5 days).
Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely.
Your infusion may be stopped or permanently discontinued if this medicine slows your breathing.
Brexanolone can make you very drowsy, and may cause you to pass out. Tell your caregivers if you feel light-headed or feel like you cannot stay awake.
Your child(ren) will need to be cared for by a family member or other caregiver during the entire time you are being treated with brexanolone.
What happens if I miss a dose?
Brexanolone is used as a single dose and does not have a daily dosing schedule.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose can cause severe drowsiness, fainting, or slowed breathing.
