Brexucabtagene autoleucel

Generic name: brexucabtagene autoleucel [ BREX-ue-KAB-ta-jeen-AH-toe-LOO-sel ]
Brand name: Tecartus
Dosage form: intravenous suspension (-)
Drug class:Miscellaneous antineoplastics

Medically reviewed by Drugs.com on Mar 15, 2021. Written by Cerner Multum.

What is brexucabtagene autoleucel?

Brexucabtagene autoleucel is an immunotherapy medicine used to treat mantle cell lymphoma in adults. brexucabtagene autoleucel is given after other treatments did not work or have stopped working.

Brexucabtagene autoleucel is made using white blood cells removed from blood that is drawn from your body through a vein.

Brexucabtagene autoleucel may also be used for purposes not listed in this medication guide.

Warnings

A common but serious side effect of this medicine is called cytokine release syndrome, which causes fever, chills, trouble breathing, vomiting, and other symptoms. Your caregivers will have medication available to quickly treat this condition if it occurs.

Before taking this medicine

You should not be treated with brexucabtagene autoleucel while you have an active infection (such as fever, chills, flu-like symptoms).

Tell your doctor if you have ever had:

• an active or chronic infection;

• a stroke;

• a seizure;

• memory problems;

• breathing problems;

• hepatitis B or C;

• HIV;

• heart problems;

• liver disease;

• kidney disease; or

• if you have received a vaccine within the past 6 weeks.

Using brexucabtagene autoleucel may increase your risk of developing other cancers, such as leukemia. Ask your doctor about this risk.

You may need to have a negative pregnancy test before starting this treatment.

Tell your doctor if you are pregnant. Brexucabtagene autoleucel may harm an unborn baby. Use effective birth control to prevent pregnancy. Talk with your doctor if you plan to become pregnant after you are treated with this medicine.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

How is brexucabtagene autoleucel given?

Brexucabtagene autoleucel is available only at an authorized hospital or clinic, and must be given by specially trained healthcare professionals.

Brexucabtagene autoleucel is given after a procedure called leukapheresis (LOO-kuh-fuh-REE-sis).

During leukapheresis, some of your blood is ...