Brolucizumab

Class: Vascular Endothelial Growth Factor Antagonists
Chemical Name: Anti-(human vascular endothelial growth factor A) (human-Oryctolagus cuniculus monoclonal ESBA1008 scFv fragment) immunoglobulin
Molecular Formula: C₁₁₆₄H₁₇₆₈N₃₁₀O₃₇₂S₈
CAS Number: 1531589-13-5
Brands: Beovu

Medically reviewed by Drugs.com on Feb 1, 2022. Written by ASHP.

Introduction

Recombinant humanized monoclonal single-chain antibody fragment; a vascular endothelial growth factor A (VEGF-A) antagonist.

Uses for Brolucizumab

Neovascular Age-related Macular Degeneration

Treatment of neovascular (wet) age-related macular degeneration (AMD). When administered every 8 or 12 weeks (depending on clinician assessment of disease activity), brolucizumab-dbll was noninferior to aflibercept administered every 8 weeks in improving visual acuity and preventing further vision loss.

Brolucizumab Dosage and Administration

Administration

Ophthalmic Administration

Administer by intravitreal injection into the affected eye(s). Only qualified clinicians should administer the drug.

Because of the risk of infection and endophthalmitis, always use proper aseptic technique when preparing and administering the drug. (See Endophthalmitis and Other Serious Ocular Effects under Cautions.)

Commercially available in single-use vials containing 6 mg of the drug for intravitreal injection. Prior to administration, allow the vial to come to room temperature. Solution should appear clear to slightly opalescent and colorless to slightly brownish-yellow; do not use if it contains particles or appears cloudy or discolored.

Withdraw entire vial contents through a sterile 5-µm, 18-gauge filter needle (provided by manufacturer) into a 1-mL syringe. Next, replace filter needle with a sterile 30-gauge, ½-inch needle for intravitreal injection. Expel air from the syringe and align plunger tip to the 0.05-mL mark on the syringe. Administer immediately following preparation.

Inject under aseptic conditions (including use of surgical hand disinfection, sterile gloves, sterile drape, sterile eyelid speculum [or equivalent], and availability of sterile paracentesis equipment [if required]) following adequate anesthesia and administration of a broad-spectrum topical microbicide to disinfect the periocular skin, eyelid, and ocular surface.

Each vial is intended for treatment of a single eye only. If the contralateral eye requires treatment, use a new vial; change the sterile field, syringe, gloves, drape, eyelid speculum, and filter and injection needles before administering brolucizumab in the other eye.

Immediately following intravitreal injection, monitor for elevation in IOP via tonometry or by checking for perfusion of the optic nerve head. (See Increased Intraocular Pressure under Cautions.)

Dosage

Adults

Neovascular Age-related Macular Degeneration

Ophthalmic

6 mg (0.05 mL of a solution containing 120 mg/mL) by intravitreal injection into the affected eye(s) once every month (approximately every 25–31 days) f...