Bromfenac

Class: Nonsteroidal Anti-inflammatory Agents
- Nonsteroidal Anti-inflammatory Agents, Ophthalmic
- NSAIAs, EENT
- NSAIDs, EENT
VA Class: CN104
Chemical Name: 2-amino-3-(4-bromobenzoyl)benzeneacetic acid sesquihydrate monosodium salt
Molecular Formula: C₁₅H₁₁BrNNaO₃
CAS Number: 120638-55-3
Brands: Xibrom

Medically reviewed by Drugs.com on Apr 21, 2022. Written by ASHP.

Introduction

Prototypical NSAIA.

Uses for Bromfenac

Postoperative Ocular Inflammation and Pain

Management of ocular inflammation and pain associated with cataract extraction.

Bromfenac Dosage and Administration

Administration

Ophthalmic Administration

Apply topically to the eye as an ophthalmic solution.

Avoid contamination of the solution container.

Do not administer while wearing contact lenses. (See Advice to Patients.)

Dosage

Available as bromfenac sodium sesquihydrate; dosage expressed in terms of bromfenac.

Adults

Postoperative Ocular Inflammation and Pain

Ophthalmic

1 drop of a 0.09% solution in the affected eye(s) twice daily, beginning 24 hours after cataract surgery and continuing through the first 2 weeks of the postoperative period.

Cautions for Bromfenac

Contraindications

• Known hypersensitivity to bromfenac sodium or any ingredient in the formulation.

Warnings/Precautions

Warnings

Bleeding

May inhibit platelet aggregation and prolong bleeding time.

May cause increased bleeding of ocular tissues (including hyphemas) when used in conjunction with ocular surgery.

Use with caution in patients with underlying bleeding tendencies or in those receiving drugs known to prolong bleeding time.

Sensitivity Reactions

Hypersensitivity Reactions

Possible cross-sensitivity with aspirin, phenylacetic acid derivatives, and other NSAIAs. Use with caution in patients with history of hypersensitivity to these drugs.

Sulfite Sensitivity

Formulation contains sodium sulfite, which may cause allergic-type reactions (including anaphylaxis and life-threatening or less severe asthmatic episodes) in certain susceptible individuals.

General Precautions

Wound-healing Complications

May slow or delay wound healing. (See Specific Drugs under Interactions.)

Ocular Effects

Use may result in keratitis. In some susceptible patients, continued use may result in epithelial breakdown, corneal thinning, corneal erosion, corneal ulceration, or corneal perforation;