Brompheniramine
Class: First Generation Antihistamines
ATC Class: R06AB01
VA Class: AH104
CAS Number: 980-71-2
Introduction
First generation antihistamines; alkylamine (propylamine) derivatives.
Uses for Brompheniramine
Allergic Rhinitis or Other Upper Respiratory Allergies
Used in fixed combination with other agents (e.g., dextromethorphan, guaifenesin, phenylephrine, pseudoephedrine) for relief of rhinorrhea, sneezing, lacrimation, itching eyes, oronasopharyngeal itching, and/or other symptoms (e.g., nasal/sinus congestion, cough) associated with allergic rhinitis (e.g., hay fever) or other upper respiratory allergies.
Use fixed-combination preparations only when symptoms amenable to each ingredient are present concurrently.
Common Cold
Used in fixed combination with other agents (e.g., phenylephrine, pseudoephedrine) for temporary relief of rhinorrhea, sneezing, lacrimation, itching eyes, oronasopharyngeal itching, and/or other symptoms associated with the common cold (e.g., nasal congestion).
Brompheniramine Dosage and Administration
Administration
Oral Administration
Administer orally with food, water, or milk to minimize gastric irritation.
Brompheniramine maleate oral solution: Use only the measuring device (e.g., calibrated dropper, cup, spoon) provided by the manufacturer.
Dosage
Brompheniramine: Available as brompheniramine maleate; dosage expressed in terms of the salt.
Dexbrompheniramine: Available as dexprompheniramine maleate; dosage expressed in terms of the salt. Dexbrompheniramine maleate available only in fixed-combination preparations.
Individualize dosage according to patient’s response and tolerance.
Fixed-combination preparations do not permit individual titration of dosages. When used in fixed combination with other agents (e.g., dextromethorphan, guaifenesin, phenylephrine, pseudoephedrine), select a dosage that is within the usual therapeutic range for each ingredient. Because combinations and dosage strengths vary for fixed-combination preparations, consult manufacturer’s product labeling for appropriate dosage of the specific preparation.
Pediatric Patients
Allergic Rhinitis, Other Upper Respiratory Allergies, or the Common Cold
Brompheniramine Maleate
OralChildren 2 to <6 years of age: 1 mg every 4 hours.
Self-medication in children 6 to <12 years of age: 2 mg every 4 hours.
Self-medication in children ≥12 years of age: 4 mg every 4 hours.
Adults
Allergic Rhinitis, Other Upper Respiratory Allergies, or the Common Cold
Brompheniramine Maleate
OralSelf-medication: 4 mg every 4 hours.
Prescribing Limits
Pediatric Patients
Allergic Rhinitis, Other Upper Respiratory Allergies, or the Common Cold
Brompheniramine Maleate
OralChildren 2 to <6 years of age: Maximum 6 mg in 24 hours.
Children 6 to <12 years of age: Maximum 12 mg in 24 hours. When used for self-medication, discontinue therapy if symptoms persist for >7 days or are accompanied by fever.
Children ≥12 years of age: Maximum 24 mg in 24 hours. When used for self-medication, discontinue therapy if symptoms persist for >7 days or are accompanied by fever.
