Cabometyx

Generic name:cabozantinib [ KA-boe-ZAN-ti-nib ]
Drug classes:Multikinase inhibitors, VEGF/VEGFR inhibitors

Medically reviewed by Judith Stewart, BPharm. Last updated on Sep 22, 2021.

What is Cabometyx?

Cabometyx is a kinase inhibitor, a type of enzyme inhibitor that blocks the action of certain protein kinases.

Cabometyx is used to treat advanced kidney cancer, sometimes in combination with another medicine called nivolumab.

Cabometyx is used to treat liver cancer (hepatocellular carcinoma) in people who have been previously treated with sorafenib.

Cabometyx is also used to treat a type of thyroid cancer called differentiated thyroid cancer (DTC) that has spread, and has progressed after treatment with a VEGFR-targeted treatment, and can no longer be treated with, or you are not able to receive radioactive iodine.

Warnings

Cabometyx may cause a perforation (a hole or tear) or a fistula (an abnormal passageway) within your stomach or intestines. This medicine can also increase your risk of serious bleeding.

Call your doctor if you have: severe stomach pain, choking or gagging when you eat or drink, unusual bleeding, bloody or tarry stools, heavy menstrual bleeding, or if you cough up blood.

Before taking this medicine

To make sure Cabometyx is safe for you, tell your doctor if you have:

• an open wound on your skin (or a wound that is still healing);

• bleeding problems (such as bloody or tarry stools, or coughing up blood or vomit that looks like coffee grounds);

• high blood pressure;

• liver disease; or

• a pre-existing dental problem.

You may need to have a negative pregnancy test before starting this treatment.

Cabozantinib may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using Cabometyx and for at least 4 months after your last dose. Tell your doctor if you think you might be pregnant.

Cabozantinib may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because Cabometyx can harm an unborn baby.

You should not breastfeed while using Cabometyx, and for at least 4 months after your last dose.

How should I take Cabometyx?

Take Cabometyx exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Do not use Cabometyx tablets in place of Cometriq (cabozantinib) capsules. Take only the pill form your doctor has prescribed. A...