Cardiolite

Generic name:Technetium Tc99m Sestamibi
Dosage form: Kit for the Preparation of Injection
Drug class:Radiologic conjugating agents

Medically reviewed by Drugs.com. Last updated on Jan 24, 2022.

Cardiolite Description

Each 5 mL vial contains a sterile, non-pyrogenic, lyophilized mixture of:

Tetrakis (2-methoxy isobutyl isonitrile) Copper (I) tetrafluoroborate - 1.0 mg
Sodium Citrate Dihydrate - 2.6 mg
L-Cysteine Hydrochloride Monohydrate - 1.0 mg
Mannitol – 20 mg
Stannous Chloride, Dihydrate, minimum (SnCl2•2H2O) - 0.025 mg
Stannous Chloride, Dihydrate, (SnCl2•2H2O) - 0.075 mg
Tin Chloride (stannous and stannic) Dihydrate, maximum
(as SnCl2•2H2O) - 0.086 mg

Prior to lyophilization the pH is 5.3 to 5.9. The contents of the vial are lyophilized and stored under nitrogen.

This drug is administered by intravenous injection for diagnostic use after reconstitution with sterile, non-pyrogenic, oxidant-free Sodium Pertechnetate Tc99m Injection. The pH of the reconstituted product is 5.5 (5.0 - 6.0). No bacteriostatic preservative is present.

The precise structure of the technetium complex is Tc99m[MIBI]6+ where MIBI is 2-methoxy isobutyl isonitrile.

PHYSICAL CHARACTERISTICS

Technetium Tc99m decays by isomeric transition with a physical half-life of 6.02 hours1. Photons that are useful for detection and imaging studies are listed in Table 1.

1

Kocher, David, C., Radioactive Decay Data Tables, DOE/TIC-11026, 108(1981)