Adakveo Injection

Generic name:crizanlizumab
Dosage form: injection
Drug class:Miscellaneous uncategorized agents

Medically reviewed by Drugs.com. Last updated on Jul 1, 2021.

INDICATIONS AND USAGE

ADAKVEO® is indicated to reduce the frequency of vasoocclusive crises (VOCs) in adults and pediatric patients aged 16 years and older with sickle cell disease.

DOSAGE AND ADMINISTRATION

Recommended Dosage

Administer ADAKVEO 5 mg/kg by intravenous infusion over a period of 30 minutes at Week 0, Week 2, and every 4 weeks thereafter.

If a dose is missed, administer ADAKVEO as soon as possible.

If ADAKVEO is administered within 2 weeks after the missed dose, continue dosing according to the patient's original schedule.

If ADAKVEO is administered more than 2 weeks after the missed dose, continue dosing every 4 weeks thereafter.

ADAKVEO may be given with or without hydroxyurea.

Preparation and Administration

ADAKVEO should be prepared and administered by a healthcare professional.

Preparation

• Use aseptic technique to prepare the solution for infusion.
• Calculate the dose (mg) and the total volume (mL) of ADAKVEO solution required, and the number of ADAKVEO vials needed based on the patient’s actual body weight.
  • Prepare 5 mg of ADAKVEO per kg of actual body weight.
• Calculate the volume of ADAKVEO to be used according to the following equation:

Dilution

Dilute ADAKVEO in 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP to a total volume of 100 mL for intravenous infusion as follows:

1. Obtain the number of vials required. One vial is needed for every 10 mL of ADAKVEO.
2. Bring vials to room temperature for a maximum of 4 hours prior to the start of preparation (piercing the first vial).
3. Visually inspect the vials.
   • Parenteral drug products should be inspected visually f.