Casimersen
Generic name: casimersen [ KAS-i-MER-sen ]
Brand name: Amondys 45
Dosage form: intravenous solution (100 mg/2 mL)
Drug class:Miscellaneous uncategorized agents
What is casimersen?
Casimersen is used to treat Duchenne muscular dystrophy in adults and children who have a certain gene mutation. Your doctor will test you for this gene mutation.
Casimersen was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to casimersen, but further studies are needed.
Casimersen may also be used for purposes not listed in this medication guide.
Warnings
Before using casimersen tell your doctor about all your medical conditions or allergies, all medicines you use, and if you are pregnant or breastfeeding.
Before taking this medicine
Tell your doctor if you have ever had kidney problems.
Tell your doctor if you are pregnant or breastfeeding.
How should I take casimersen?
Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using casimersen.
Casimersen is given as an infusion into a vein, usually once per week. A healthcare provider will give you this injection.
casimersen must be given slowly, and the infusion can take 35 to 60 minutes to complete.
Your kidney function may need to be checked while you are using this medicine.
Casimersen doses are based on weight. Your dose needs may change if you gain or lose weight.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your casimersen injection.
What happens if I overdose?
Since casimersen is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while taking casimersen?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Casimersen side effects
Get emergency medical help if you have signs of an allergic reaction:hives, itching, rash, blistering or peeling; fever; difficult breathing; swelling of your face, lips, tongue, or throat.
Casimersen may cause serious side effects. Call your doctor at once if you have:
pink, brown, or red urine;
foamy urine; or
swelling in your face, hands, feet, or stomach.
Common side effects of casimersen may include:
