Cefobid
Generic name:cefoperazone
Dosage form: injection
Drug class:Third generation cephalosporins
Medically reviewed by Drugs.com. Last updated on Mar 22, 2022.
PHARMACY BULK PACKAGE
NOT FOR DIRECT INFUSION
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Cefobid Description
Cefobid® (cefoperazone), formerly known as cefoperazone sodium, is a sterile, semisynthetic, broad-spectrum, parenteral cephalosporin antibiotic for intravenous or intramuscular administration. It is the sodium salt of 7-[(R)-2-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-2-(p-hydroxyphenyl)acetamido-3-[[(1-methyl-H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate. Its chemical formula is C25H26N9NaO8S2 with a molecular weight of 667.65. The structural formula is given below:
Cefobid contains 34 mg sodium (1.5 mEq) per gram. Cefobid is a white powder which is freely soluble in water. The pH of a 25% (w/v) freshly reconstituted solution varies between 4.5–6.5 and the solution ranges from colorless to straw yellow depending on the concentration.
Cefobid in crystalline form is supplied in vials equivalent to 1 g or 2 g of cefoperazone.
A pharmacy bulk package is a container of a sterile preparation for parenteral use that contains many single doses.
This Pharmacy Bulk Package is for use in a pharmacy admixture service; it provides many single doses of cefoperazone for addition to suitable parenteral fluids in the preparation of admixtures for intravenous infusion. (See DOSAGE AND ADMINISTRATION, and DIRECTIONS FOR PROPER USE OF PHARMACY BULK PACKAGE.)
Cefobid - Clinical Pharmacology
High serum and bile levels of Cefobid are attained after a single dose of the drug. Table 1 demonstrates the serum concentrations of Cefobid in normal volunteers following either a single 15-minute constant rate intravenous infusion of 1, 2, 3 or 4 grams of the drug, or a single intramuscular injection of 1 or 2 grams of the drug.
