cefTAZidime/Avibactam
Class: Third Generation Cephalosporins
Chemical Name: [6R-[6α,7β(Z)]]-1-[[7-[[(2-Amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-pentahydrate, inner salt, hydroxide, pyridinium
Molecular Formula: C22H22N6O7S2 • 5H2OC7H10N3O6SNa
CAS Number: 78439-06-2
Introduction
Antibacterial; β-lactam antibiotic; fixed combination of ceftazidime (a third generation cephalosporin) and avibactam (a non-β-lactam β-lactamase inhibitor).
Uses for cefTAZidime/
Intra-abdominal Infections
Treatment of complicated intra-abdominal infections caused by susceptible Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, K. pneumoniae, Proteus mirabilis, Providencia stuartii, or Pseudomonas aeruginosa; used in conjunction with metronidazole.
Reserve for use in patients with limited or no alternative treatment options; clinical safety and efficacy data are limited.
Urinary Tract Infections
Treatment of complicated urinary tract infections, including pyelonephritis, caused by susceptible E. coli, Citrobacter freundii, C. koseri, E. aerogenes, E. cloacae, K. pneumoniae, Proteus, or Ps. aeruginosa.
Reserve for use in patients with limited or no alternative treatment options; clinical safety and efficacy data are limited.
cefTAZidime/
Administration
Administer by IV infusion.
IV Administration
For solution compatibility information, see Compatibility under Stability.
Reconstitution
Reconstitute single-dose vials of ceftazidime and avibactam labeled as containing 2.5 g (ceftazidime 2 g and avibactam 0.5 g) by adding 10 mL of compatible IV solution (sterile water for injection, 0.9% sodium chloride injection, 5% dextrose injection, 2.5% dextrose and 0.45% sodium chloride injection, lactated Ringer's injection) to the vial; mix gently.
Volume of reconstituted solution is approximately 12 mL; approximate concentration is ceftazidime 167 mg/mL and avibactam 42 mg/mL.
Dilution
Prior to IV infusion, reconstituted solutions must be further diluted.
To prepare indicated dose, withdraw appropriate volume of reconstituted solution from the vial and add to a compatible IV solution to achieve a total final volume of 50–250 mL in an IV infusion bag. (See Table 1.) Solution should appear clear and colorless to light yellow.
With the exception of sterile water for injection, dilute using same IV solution used for reconstitution; dilute with any other compatible IV solution if sterile water for injection was used for reconstitution.
Mix diluted solution gently to ensure the drug is completely dissolved.
