Adapalene Cream

Dosage form: cream
Drug class:Topical acne agents

Medically reviewed by Drugs.com. Last updated on Mar 1, 2022.

Rx Only

For topical use only. Not for ophthalmic, oral or intravaginal use.

DESCRIPTION:

Adapalene Cream, 0.1%, contains adapalene 0.1% in an aqueous cream emulsion consisting of carbomer 934P, cyclomethicone, edetate disodium, glycerin, methyl glucose sesquistearate, methylparaben, PEG-20 methyl glucose sesquistearate, phenoxyethanol, propylparaben, purified water, squalane, and trolamine.

The chemical name of adapalene is 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid. It is a white to off-white powder which is soluble in tetrahydrofuran, sparingly soluble in ethanol, and practically insoluble in water. The molecular formula is C28H28O3 and molecular weight is 412.52. Adapalene is represented by the following structural formula:

CLINICAL PHARMACOLOGY:

Mechanism of Action:

Adapalene acts on retinoid receptors. Biochemical and...