Cerubidine (Intravenous)
Generic name:daunorubicin (intravenous route) [ daw-noe-ROO-bi-sin ]
Drug class:Antibiotics / antineoplastics
Medically reviewed by Drugs.com. Last updated on Apr 10, 2022.
Must be given into a rapidly flowing IV infusion and must never be given by the IM or subQ route, as severe local tissue necrosis will occur if there is extravasation during administration. Myocardial toxicity manifested in its most severe form by potentially fatal congestive heart failure may occur either during therapy or months to years after termination of therapy. The incidence of myocardial toxicity increases after a total cumulative dose exceeding 400 to 550 mg/m(2) in adults, 300 mg/m(2) in children more than 2 years of age, or 10 mg/kg in children less than 2 years of age. Severe myelosuppression occurs when used in therapeutic doses; this may lead to infection or hemorrhage. Dosage should be reduced in patients with impaired hepatic or renal function .
Commonly used brand name(s)
In the U.S.
- Cerubidine
Available Dosage Forms:
- Solution
Therapeutic Class: Antineoplastic Agent
Chemical Class: Anthracycline
Uses for Cerubidine
Daunorubicin belongs to the general group of medicines known as antineoplastics. It is used to treat some kinds of cancer.
Daunorubicin seems to interfere with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by daunorubicin, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.
Before you begin treatment with daunorubicin, you and your doctor should talk about the good this medicine will do as well as the risks of using it.
Daunorubicin is to be administered only by or under the immediate supervision of your doctor.
Before using Cerubidine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Although daunorubicin is used in children, there is no specific information comparing use in children with use in other age groups.
Geriatric
Heart problems are more likely to occur in the elderly, who are usually more sensitive to the effects of daunorubicin. The elderly may also be more likely to have blood problems.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before takin..
