Ciprofloxacin (EENT)
Class: Antibacterials
Chemical Name: 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
Molecular Formula: C17H18FN3O3•ClH•H2O
CAS Number: 85721-33-1
Brands: Cetraxal, Ciloxan, Otiprio
Introduction
Antibacterial; fluoroquinolone.
Uses for Ciprofloxacin (EENT)
Bacterial Ophthalmic Infections
Topical treatment of bacterial conjunctivitis caused by susceptible Staphylococcus aureus, S. epidermidis, Streptococcus pneumoniae, or Haemophilus influenzae (0.3% ophthalmic solution).
Topical treatment of bacterial conjunctivitis caused by susceptible S. aureus, S. epidermidis, S. pneumoniae, viridans streptococci, or H. influenzae (0.3% ophthalmic ointment).
Mild, acute bacterial conjunctivitis often resolves spontaneously without anti-infective treatment. Although topical ophthalmic anti-infectives may shorten time to resolution and reduce severity and risk of complications, avoid indiscriminate use of topical anti-infectives. Treatment of acute bacterial conjunctivitis generally is empiric; use of a broad-spectrum topical ophthalmic antibacterial usually recommended. In vitro staining and/or cultures of conjunctival material may be indicated in management of recurrent, severe, or chronic purulent conjunctivitis or when acute conjunctivitis does not respond to initial empiric topical treatment.
Topical treatment of keratitis (corneal ulcer) caused by susceptible S. aureus, S. epidermidis, S. pneumoniae, viridans streptococci, Serratia marcescens, or Pseudomonas aeruginosa (0.3% ophthalmic solution).
Because bacterial keratitis may be associated with subsequent loss of vision as the result of corneal scarring or topographic irregularities and because untreated or severe bacterial keratitis may result in corneal perforation with potential for endophthalmitis and possible loss of the eye, optimal management involves rapid evaluation and diagnosis, timely initiation of treatment, and appropriate follow-up. Treatment of community-acquired bacterial keratitis generally is empiric; use of a broad-spectrum topical ophthalmic antibacterial usually recommended. Subconjunctival anti-infectives may be necessary if scleral spread or perforation is imminent. In vitro staining and/or cultures of corneal material are indicated in management of keratitis involving corneal infiltrates that are central, large, and extend to the middle to deep stroma or when keratitis is chronic or unresponsive to a broad-spectrum topical anti-infective.
Bacterial Otic Infections
Topical treatment of acute otitis externa caused by susceptible S. aureus or Ps. aeruginosa (0.2% otic solution).
Intratympanic treatment of bilateral otitis media with effusion in pediatric patients undergoing tympanostomy tube placement (6% otic suspension for intratympanic use).
Fixed combination of ciprofloxacin and dexamethasone (ciprofloxacin 0.3% and dexamethasone 0.1% otic suspension): Topical treatment of acute otitis externa caused by susceptible S. aureus or Ps. aeruginosa.
Fixed combination of ciprofloxacin and hydrocortisone (ciprofloxacin 0.2% and hydrocortisone 1% otic suspension): Topical treatment of acute otitis externa caused by susceptible S. aureus, <...
