Cladribine (injection)
Generic name: cladribine (injection) [ KLAD-ri-been ]
Brand name: Leustatin
Dosage form: intravenous solution (1 mg/mL)
Drug class:Antimetabolites
What is cladribine?
Cladribine is a cancer medicine that is used to treat hairy cell leukemia (a type of blood cancer).
Cladribine may also be used for purposes not listed in this medication guide.
Warnings
Cladribine can increase your risk of bleeding or infection. Call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, chills, cough, chest pain, mouth sores, skin sores, sore throat, trouble breathing).
Very high doses of cladribine injection can cause nerve damage or paralysis that may not be reversible. However, this effect is rare when cladribine is given in recommended doses.
Before taking this medicine
You should not use cladribine if you are allergic to it.
Tell your doctor if you have ever had:
heart problems;
liver or kidney disease; or
weak immune system (caused by disease or by using certain medicine).
Cladribine may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.
You should not breastfeed while using cladribine.
How is cladribine given?
Cladribine is given as an infusion into a vein. A healthcare provider will give you this injection.
Cladribine is usually given around the clock for 7 days in a row. Your doctor will determine how many 7- day treatments you will receive and how often.
Cladribine can increase your risk of bleeding or infection. You will need frequent medical tests, and your next dose may be delayed based on the results.
If cladribine accidentally gets on your skin, wash it thoroughly with soap and warm water.
What happens if I miss a dose?
Since this medication is given in a healthcare setting around the clock, you will not miss a dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Very high doses of cladribine injection can cause nerve damage. In some people, this has resulted in loss of movement (paralysis) that may not be reversible. However, such severe symptoms are rare when cladribine is given in recommended doses. Talk with your doctor if you have concerns about this risk.
What should I avoid while receiving cladribine?
Do not receive a "live" vaccine while using cladribine, or you could...
