Clonidine Patch

Dosage form: patch,
Drug class:Antiadrenergic agents, centrally acting

Medically reviewed by Drugs.com. Last updated on Dec 1, 2020.

DESCRIPTION

Clonidine Transdermal System, USP is a transdermal system providing continuous systemic delivery of clonidine for 7 days at an approximately constant rate. Clonidine is a centrally acting alpha-agonist hypotensive agent. It is an imidazoline derivative with the chemical name 2, 6-dichloro-N-2-imidazolidinylidenebenzenamine and has the following chemical structure:

Meets USP Drug Release Test 4.

System Structure and Components

Clonidine Transdermal System, USP is a multi-layered film, 0.2 mm thick, containing clonidine as the active agent. The system areas are 4.1 cm2 (0.1 mg per day for one week), 8.2 cm2 (0.2 mg per day for one week) and 12.3 cm2 (0.3 mg per day for one week) and the amount of drug released is directly proportional to the area (see Release Rate Concept). The composition ...