Coagulation factor Xa
Generic name: coagulation factor Xa [ koe-AG-ue-LAY-tion-FAK-tor-Xa ]
Brand name: Andexxa
Dosage form: intravenous powder for injection (recombinant, inactivated 100 mg; recombinant, inactivated 200 mg)
Drug class:Anticoagulant reversal agents
What is coagulation factor Xa?
Coagulation factor Xa is a protein that reverses the effects of certain anticoagulant medications that are used to treat or prevent blood clots. Reversing anticoagulant medicine is necessary if you have uncontrolled or life-threatening bleeding as a result of how that medicine works.
Coagulation factor Xa is used to treat uncontrolled bleeding in people who take the anticoagulantsrivaroxaban (Xarelto) and apixaban (Eliquis).
Coagulation factor Xa was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, healthy volunteers responded to coagulation factor Xa, but further studies are needed.
Coagulation factor Xa may also be used for purposes not listed in this medication guide.
Warnings
This medicine is used to reverse the effects of anticoagulant medication, which may increase your risk of a blood clot, heart attack, stroke, or death. Watch for symptoms such as chest pain, sudden numbness or weakness, problems with vision or speech, and swelling or redness in an arm or leg.
Before taking this medicine
You should not be treated with coagulation factor Xa if you have had an allergic reaction to clotting factor medicine.
In an emergency, you may not be able to tell caregivers about your health conditions. Make sure any doctor caring for you afterward knows you received coagulation factor Xa.
In an emergency, you may not be able to tell caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you received this medicine.
How is coagulation factor Xa given?
Coagulation factor Xa is given as an infusion into a vein. A healthcare provider will give you this injection.
This medicine must be given slowly, and the infusion can take at least 2 hours to complete.
Once your bleeding has been controlled, you may need to begin using anticoagulant medication again to prevent future blood clots. Follow your doctor's instructions very carefully.
What happens if I miss a dose?
Because you will receive coagulation factor Xa in a clinical setting, you are not likely to miss a ...
