Cobicistat and darunavir

Generic name: cobicistat and darunavir [ koe-BIK-i-stat-and-dar-UE-na-vir ]
Brand name: Prezcobix
Dosage form: oral tablet (150 mg-800 mg)
Drug class:Antiviral combinations

Medically reviewed by Drugs.com on May 2, 2022. Written by Cerner Multum.

What is cobicistat and darunavir?

Cobicistat and darunavir is a combination medicine given with other medicines to treat human immunodeficiency virus (HIV) in adults, the virus that can cause acquired immunodeficiency syndrome (AIDS). cobicistat and darunavir is not a cure for HIV or AIDS.

Cobicistat and darunavir is for use in people who weigh at least 88 pounds (40 kilograms).

Cobicistat and darunavir may also be used for purposes not listed in this medication guide.

Warnings

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

Call your doctor at once if you have signs of a serious side effect--upper stomach pain, vomiting, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes), fever, tiredness, eye redness, muscle or joint pain, skin sores, or a skin rash with blistering.

Before taking this medicine

You should not take cobicistat and darunavir if you are allergic to cobicistat or darunavir.

Some medicines can cause unwanted or dangerous effects when used with cobicistat and darunavir. Your doctor may change your treatment plan if you also use:

• alfuzosin;

• cisapride;

• colchicine;

• elbasvir and grazoprevir (Zepatier);

• naloxegol;

• rifampin;

• sildenafil (Revatio, for treating pulmonary arterial hypertension);

• St. John's wort;

• heart medication--dronedarone, ivabradine, ranolazine;

• medicine to lower cholesterol--lomitapide, lovastatin, simvastatin;