Codrix
Generic name:acetaminophen and codeine phosphate
Dosage form: tablets
Drug class:Narcotic analgesic combinations
Medically reviewed by Drugs.com. Last updated on Aug 23, 2021.
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The Codrix brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Codrix Description
Acetaminophen and codeine is supplied in tablet form for oral administration.
Acetaminophen, 4'-hydroxyacetanalide, a slightly bitter, white, odorless, crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic. It has the following structural formula:
Codeine phosphate, 7,8-didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol phosphate (1:1) (salt) hemihydrate, a white crystalline powder, is a narcotic analgesic and antitussive. It has the following structural formula:
Each tablet contains:
Acetaminophen 500 mg
Codeine phosphate 15 mg
In addition each tablet contains the following inactive ingredients: Colloidal silicon dioxide, crospovidone, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, povidone, pregelatinized starch and stearic acid.
Codrix - Clinical Pharmacology
This product combines the analgesic effects of a centrally acting analgesic, codeine, with the peripherally acting analgesics, acetaminophen.
Pharmacokinetics
The behavior of the individual components is described below.
Codeine: Codeine is readily absorbed from the gastrointestinal tract. It is rapidly distributed from the intravascular spaces to the various body tissues, with preferential uptake by parenchymatous organs such as the liver, spleen and kidney. Codeine crosse...
