Cormax Cream

Generic name:clobetasol propionate
Dosage form: cream
Drug class:Topical steroids

Medically reviewed by Drugs.com. Last updated on May 23, 2022.

For Dermatologic Use Only - Not for Ophthalmic Use.

Cormax Cream Description

Cormax Cream (Clobetasol Propionate Cream, USP) contains the active compound clobetasol propionate, a synthetic corticosteroid, for topical dermatologic use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity.
Chemically, 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione,17-propionate and it has the following structural formula: Clobetasol propionate has the molecular formula C25H3CIFO5 and a molecular weight of 467. It is a white to cream-colored crystalline powder insoluble in water.
Each gram of Cormax Cream contains 0.5 mg clobetasol propionate in a base composed of white petrolatum, cetyl alcohol, stearyl alcohol, lanolin oil, PEG-8 stearate, polysorbate 60, glycol stearate, propylparaben, propylene glycol, methylparaben, sodium citrate, citric acid and purified water.

Cormax Cream - Clinical Pharmacology

The corticosteroids are a class of compounds comprising steroid hormones secreted by the adrenal cortex and their synthetic analogs. In pharmacologic doses, corticosteroids are used primarily for their anti-inflammatory and/or immunosuppressive effects. Topical corticosteroids such as clobetasol propionate are effective in the treatment of corticosteroid-­responsive dermatoses primarily because of their anti-inflammatory, antipruritic, and vasoconstrictive actions. However, while the physiologic, pharmacologic, and clinical effects of the corticosteroids are well known, the exact mechanisms of their actions in each disease are uncertain.
Clobetasol propionate, a corticosteroid, has been shown to have topical (dermatologic) and systemic pharmacologic and metabolic effects characteris­tic of this class of drugs.

Pharmacokinetics

The extent of percutaneous absorption of topical corticosteroids, including clobetasol propionate, is determined by many factors, including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings (see DOSAGE AND ADMINISTRATION).
As with all topical corticosteroids, clobeta